The Reds visit Hill Dickinson Stadium for the first time for Sunday's 2pm BST kick-off in the Premier League.
Here are 14 facts and figures to know ahead of the 248th instalment of the local rivalry, courtesy of LFC statistician Ged Rea and Opta...
Liverpool won 101 of the previous 247 derbies, with 78 draws and 68 defeats. In league fixtures, the Reds have won 84 and lost 59.
Victory on Sunday would see Liverpool tie the number of wins at Everton at 35-35.
The Reds won their last two Premier League games against the Blues, though both came at Anfield. They last won three consecutive league Merseyside derbies between April 2016 and April 2017.
Everton won just one of their last 14 Premier League home fixtures versus Liverpool, though 10 of those games finished level.
Having won six of their first 15 Premier League meetings with Liverpool between 1992 and 1999 (40 per cent – drew six, lost three), Everton have won just five of their last 52 league Merseyside derbies since the start of 2000 (9.6 per cent – drew 20, lost 27).
The Reds have lost only two of the last 33 derbies in league and cup.