Anfield is the stage for the fourth meeting between the clubs this season, with the action getting under way at 3pm BST.
Opta and club statistician Ged Rea have compiled the following facts and figures to preview the game...
**Palace have prevailed in all three of the previous meetings this season – on penalties in the Community Shield (after a 2-2 draw), 2-1 in the league at Selhurst Park and 3-0 at Anfield in the Carabao Cup.**
No team has ever beaten the Reds four times in the same season.
**In the Premier League, Liverpool have won 20 of the previous 33 clashes, with six draws and seven defeats.**
Across those encounters, 107 goals have been scored in total – 72 of them by the Reds.
**Liverpool have won six of their last 10 Premier League games, more than in their previous 18 combined, and could win three league matches in a row for a fourth time this season.**
The Reds have lost just one of their last 18 Premier League matches at Anfield in the month of April, although that defeat did come against Palace in 2024.
**There have been nine 90th-minute winning goals in Liverpool's Premier League fixtures this season (four winners, five defeats) – two more than in any other team's games in a season in Premier League history.**