We know one key American, Chris Richards, will not be playing in the Premier League this weekend because of his ankle injury. As for the others, there are still significant non-World Cup stakes involved.
Starting near the top of the table is Tyler Adams, whose Bournemouth side is already bound for Europe. Bournemouth would need either a win or draw, along with a Liverpool victory and an Aston Villa loss, to qualify for the Champions League. Outside of that scenario, the club appears headed for the Europa League. The Cherries will certainly have one eye on the scoreboard to see if results break their way.
Closer to the bottom of the table, Brenden Aaronson and Leeds still have a role to play in the relegation race. Leeds are safe, but they face West Ham, who need both a win and a Tottenham loss to Everton to remain in the Premier League.
Then there is Antonee Robinson, whose Fulham side has little left to play for against Newcastle. The hope will simply be that nothing unusual happens in that match as the defender continues ramping up for World Cup duty.