The Magpies went close to scoring inside the opening 60 seconds as Nico González's long-range pass was cleverly headed into Anthony Elanga's path by Amar Dedić but the Swedish winger's cross-cum shot was turned out for a corner by Archie Gray.
Harvey Barnes, who netted a second half brace in Wednesday's 3-2 win against West Bromwich Albion, latched onto Yoane Wissa's pass but the Burnley-born winger directed his attempt from the edge of the box over the crossbar.
Head coach Matthias Jaissle has made six changes from Wednesday's Carabao Cup second round win against West Bromwich Albion, with Nico making his Magpies debut following the Spanish midfielder's transfer from Manchester City.
Lukáš Horníček, Lewis Miley, Anthony Elanga, Barnes and Yoane Wissa return to the starting XI after the quintet all started in United's 2-2 draw against Liverpool last weekend.
The Magpies are unbeaten in their last five Premier League matches against Spurs and were victorious in their previous trip to the Tottenham Hotspur Stadium as goals from Malick Thiaw and Jacob Ramsey secured a 2-1 win in February.
**Newcastle United:** Lukáš Horníček, Lewis Hall, Sven Botman, Nico González, Yoane Wissa, Harvey Barnes, Malick Thiaw (c), Anthony Elanga, Joe Willock, Amar Dedić, Lewis Miley.
**Subs not used:** Ewen Jaouen, Fabian Schär, Aladji Bamba, Sean Steur, Bazoumana Touré, Jacob Murphy, Nick Woltemade, Jacob Ramsey, Leo Shahar.