Villa are looking to build on last month’s opening night win in Brugge.
Unai Emery has handed winger Ibrahim Mbaye a second Villa start in Wednesday night’s Champions League clash with Fenerbahce.
The £47million summer signing is among three changes to the team from Saturday’s 2-2 draw with Brentford.
Aaron Wan-Bissaka starts at left-back in place of the injured Matteo Ruggeri, while Ross Barkley is in midfield in place of Joao Gomes.
Mbaye’s only other start was in last month’s 3-1 Carabao Cup win at Coventry.
The 18-year-old replaces Emi Buendia in the starting line-up as Villa hunt their first home win of the season.
Midfielder Leon Goretzka also features in a squad for the first time since joining in the summer.
Villa have an imperious recent record on their own turf in Europe, winning 18 out of 20 matches in the last three seasons.
Former Villa loanee Marco Asensio has been left out of the visiting side’s squad due to concern over a knee injury.